Publications by authors named "M Di Pierro"
Non-clear cell renal cell carcinoma narrative review: where we are in 2024.
Transl Cancer Res
November 2024
Article Synopsis
- Advances in understanding non-clear cell renal cell carcinoma (RCC) have improved due to better molecular and genetic testing, helping to identify specific subtypes and personalize treatment.
- Representation in clinical trials for rare non-papillary RCC variants is limited, making evidence-based management difficult.
- The shift toward molecular diagnostics is enhancing our knowledge of RCC behaviors and responses to treatments, although most evidence comes from smaller clinical studies rather than extensive trials.
Article Synopsis
- The study assessed the effectiveness of poly(ADP-ribose)polymerase inhibitors (PARPi) and platinum chemotherapy in men with prostate cancer (PC) and specific genetic mutations related to DNA repair.
- It utilized data from the PROMISE consortium to compare outcomes between three groups based on their mutation profiles: one with direct BRCA complex interactions and two without.
- Results showed that patients with BRCA mutations had significantly better responses to PARPi, including higher PSA response rates and longer progression-free survival, compared to those without direct BRCA interactions.
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that died 52,000 years ago retained its ancient genome architecture. We use PaleoHi-C to map chromatin contacts and assemble its genome, yielding 28 chromosome-length scaffolds.
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- This study investigates the effectiveness of two surfactant administration methods—INtubate-RECruit-SURfactant-Extubate (IN-REC-SUR-E) and less invasive surfactant administration (LISA)—on improving BPD-free survival in preterm infants with respiratory distress syndrome (RDS).
- A total of 382 preterm infants, born at 24-27 weeks' gestation and not intubated at birth, will be randomly assigned to either method within the first 24 hours of life. The primary outcome being measured is a combination of death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.
Recent advances chromatin capture, imaging techniques, and polymer modeling have dramatically enhanced quantitative understanding of chromosomal folding. However, the dynamism inherent in genome architectures due to physical and biochemical forces and their impact on nuclear architecture and cellular functions remains elusive. While imaging of chromatin in four dimensions is becoming more common, there is a conspicuous lack of physics-based computational tools appropriate for revealing the forces that shape nuclear architecture and dynamics.
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