Publications by authors named "M Di Iorio"

Background: Modern nerve-to-nerve transfers are a significant advancement in peripheral nerve surgery. Nerve transfers involve transferring donor nerves or branches to recipient nerves close to the motor end unit, leading to earlier reinnervation and preservation of the musculotendinous units in proximal nerve injuries. After nerve reinnervation, function may be superior to traditional tendon transfer techniques in terms of strength and independent motion.

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Lumpy skin disease virus ( family- genus) is the aetiological agent of LSD, a disease primarily transmitted by hematophagous biting, affecting principally cattle. Currently, only live attenuated vaccines are commercially available, but their use is limited to endemic areas. There is a need for safer vaccines, especially in LSD-free countries.

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The increasing use of intermittent aeration controllers in wastewater treatment plants (WWTPs) aims to reduce aeration costs via continuous ammonia and oxygen measurements but faces challenges in detecting sensor and process anomalies. Applying machine learning to this unbalanced, multivariate, multiclass classification challenge requires much data, difficult to obtain from a new plant. This study develops a machine learning algorithm to identify anomalies in intermittent aeration WWTPs, adaptable to new plants with limited data.

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Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

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Article Synopsis
  • HyperCKaemia, or elevated serum creatine kinase (CK), is frequently seen in various myopathies but can also occur in neurological disorders, making diagnosis challenging.
  • A case of a 58-year-old man illustrates the complexity, as he had a long history of muscle cramps and high CK levels, and was diagnosed with Charcot-Marie-Tooth disease type 1A through genetic testing.
  • Further genetic testing revealed a new variant related to dystrophinopathy, emphasizing the need to thoroughly investigate high CK levels in patients, even those with neurogenic disorders, to ensure proper monitoring for possible myopathy-related complications.
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