Publications by authors named "M Di Giovan Paolo"
Nutritional approach has been intensely investigated in inflammatory bowel disease (IBD) patients, but, despite many sparse reports, at present, there is not a universally accepted specific diet. In fact, nutritional requirements and, therefore, the ideal diet, may vary according to disease type, extension and activity. Among nutritional related issue in IBD, obesity has become a relevant one.
View Article and Find Full Text PDFUstekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Only limited real-life data on the long-term outcomes of CD patients treated with UST are available. This study assessed UST's long-term effectiveness and safety in a large population-based cohort of moderate to severe CD patients.
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- - The study focuses on analyzing the safety and quality of fish sauce made from fermented anchovies from Salerno, Italy, by examining levels of heavy metals and histamine during different production methods.
- - Researchers measured heavy metals (cadmium, lead, mercury) and polycyclic aromatic hydrocarbons in raw and processed anchovies, with findings showing all levels were below safe limits as set by European legislation.
- - Histamine levels were also assessed, indicating that while the highest concentrations appeared in certain stages, they remained compliant with regulatory standards, emphasizing the necessity of selecting quality raw materials and monitoring production processes.
In this pilot study, we assessed the role of autophagy in Crohn's Disease (CD), particularly in patients with a stenosing phenotype. Through the analysis of biopsied specimens from 36 patients, including 11 controls and 25 CD patients, categorized into inflammatory and stenosing groups, we identified a significant reduction in the autophagosomal marker Lc3b-II in patients with active inflammation and stenosis. This was paralleled by an increase in oxidative stress markers, including sNOX2-dp and H2O2, and a decrease in the antioxidant capacity measured by HBA, suggesting an imbalance in autophagy and oxidative stress mechanisms.
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- The study focuses on the Bagnolese sheep, a breed in Campania that produces milk for Pecorino Bagnolese cheese, and aims to analyze its milk production traits and the genetic impact of the DGAT1 gene.
- Researchers recorded milk quantity and assessed protein and fat content using specific methods, alongside genotyping to investigate genetic variations at DGAT1.
- Results indicated that Bagnolese sheep with the CT genotype at the g.5553 SNP of DGAT1 had higher fat and protein yields, suggesting this genotype could serve as a marker for improving milk production in the breed.