Publications by authors named "M Di Gioacchino"
Article Synopsis
- Bacterial Lysates are used as immunostimulants to help prevent respiratory tract infections (RTIs) by enhancing both innate and adaptive immune responses.
- Studies indicate that they can boost immune function, support epithelial barriers, and lead to increased production of specific antibodies without significant side effects.
- However, many studies on Bacterial Lysates are low quality and lack rigorous controls, suggesting that more thorough and well-designed clinical trials are needed to confirm their effectiveness in preventing RTIs.
Article Synopsis
- Wetlands deliver essential ecosystem services, but are increasingly threatened by pollutants, particularly plastics and microplastics (MPs), which have been under-researched in these environments.
- This study examined the abundance of MPs in two common aquatic insect groups collected from twelve Mediterranean wetland zones in Andalusia, exploring how proximity to landfills and the presence of certain waterbirds influenced MP levels.
- Results revealed a total of 571 MPs, mainly blue fibers, with higher contamination near landfills and at sites with landfill-feeding birds; additionally, aquatic insects can be effective indicators in monitoring MP pollution to target conservation efforts.
Could Raman spectroscopy investigate the changes of cell oxidative stress status in thyroid diseases? A pilot study on cytological samples.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Article Synopsis
- * In a study of 28 patients, RS was used to analyze thyroid cytological samples from fine needle aspirations (FNA) to evaluate cell oxidative stress, a major cancer risk factor.
- * The findings categorized patients based on changes in Raman spectra related to oxidative stress and carotenoid presence, suggesting a link between oxidative stress and thyroid diseases that could inform future research on biomarkers.
Article Synopsis
- - Autoimmune skin disorders like Psoriasis, Vitiligo, and Alopecia Areata stem from genetic factors, environmental influences, and immune system issues, and there is a connection between autoimmune thyroid diseases and these skin conditions, particularly urticaria.
- - The review explores links between autoimmune thyroiditis and various autoimmune skin disorders, highlighting shared genetic markers, immune mechanisms, and clinical relationships, such as IL-23 receptor gene variants increasing the risk for specific conditions.
- - Common mechanisms like immune system breakdown and oxidative stress lead to inflammation, with similar antigens in skin cells and thyroid cells possibly explaining their co-occurrence, thus stressing the need for thorough diagnosis and treatment strategies, while suggesting more research on immunological pathways and biomarkers
In recent years, cancer management has benefitted from new effective treatments, including immunotherapy. While these therapies improve cancer survival rates, they can alter immune responses and cause long-term side effects, of which gonadotoxic effects and the potential impact on male and female fertility are growing concerns. Immunotherapies, such as immune checkpoint inhibitors, immunomodulators, monoclonal antibodies, and CAR-T, can lead to elevated levels of proinflammatory cytokines and immune-related adverse events that may exacerbate fertility problems.
View Article and Find Full Text PDF