Ultrasound guided procedures in the head and neck: a clinician centered model.

Background: US guided sampling is a validated diagnostic approach for non-thyroid deep head and neck masses.

Aim: To describe the setting of a clinician-driven Lump Clinic and analyze a monoinstitutional 7-year database of 849 patients undergoing US-guided sampling.

Methods: FNA with Rapid OnSite Evalutation (ROSE) was the first diagnostic step.

Transformations of crude oil into tar: a case study from a plastitar-contaminated site in NE Sicily, Italy (Western Mediterranean).

This study examines the aging of industrial crude oil to simulate the chemical transformations that occur when it is exposed to environmental conditions over time. It was triggered by the finding of plastitar - a mixture of tar and plastic waste - on the coast of Milazzo, Sicily. Research began with a chemical characterization of the tar component of plastitar, followed by aging experiments designed to simulate environmental conditions such as seawater, UV light and sunlight.

A combinatorial culture strategy to develop pseudomyxoma peritonei organoid models.

Background And Objectives: Few preclinical models of pseudomyxoma peritonei (PMP) have been developed, probably due to the tumor's low incidence and its peculiar characteristics of slow growth. Therefore, there is a need to develop more refined PMP models that better reflect its characteristics. The aim of the study is to develop a culture strategy to generate organoid models derived from PMP patient samples.

Extracellular Vesicles: Diagnostic and Therapeutic Applications in Cancer.

In recent years, knowledge of cell-released extracellular vesicle (EV) functions has undergone rapid growth. EVs are membrane vesicles loaded with proteins, nucleic acids, lipids, and bioactive molecules. Once released into the extracellular space, EVs are delivered to target cells that may go through modifications in physiological or pathological conditions.