Publications by authors named "M Desnos"
Article Synopsis
- A study analyzed the management of hypertrophic cardiomyopathy (HCM) in 1431 patients across 26 French medical centers, revealing differences between expert and non-expert facilities.
- Patients at non-expert centers were typically older and more likely to experience severe symptoms, while also having fewer genetic confirmations of their condition compared to those treated at expert sites.
- The findings highlight significant disparities in diagnostic and treatment approaches for HCM, suggesting that non-sarcomeric forms of the disease may be underrecognized and improperly managed outside of specialized centers.
We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to survive in harsh environments, which can make them appealing candidates for transplantation in diseases requiring supply of new myogenic cells.
View Article and Find Full Text PDFBackground: In addition to scalability, human embryonic stem cells (hESCs) have the unique advantage of allowing their directed differentiation toward lineage-specific cells.
Objectives: This study tested the feasibility of leveraging the properties of hESCs to generate clinical-grade cardiovascular progenitor cells and assessed their safety in patients with severe ischemic left ventricular dysfunction.
Methods: Six patients (median age 66.