Publications by authors named "M Deodhar"
Article Synopsis
- B-cell depletion therapy (BCDT) has been used for about 20 years to treat autoimmune diseases, primarily utilizing monoclonal antibodies that target CD20 to eliminate B cells through various effector functions.
- Recent advancements include diverse BCDT approaches, such as enhanced monoclonal antibodies, CAR-T cell treatments, and bispecific T-cell engagers (TCEs), which show improved B-cell depletion for hematologic cancers and potential benefits for autoimmune diseases.
- This review explores the development of BCDTs for autoimmune diseases, focusing on their design, mechanisms of action, safety, efficacy, and the promise presented by TCEs in effectively engaging T cells for better B-cell depletion.
Aims And Objective: To evaluate the patients at risk of venous thromboembolism (VTE) based on Caprini VTE risk assessment scale and the effect of implementation of this scale on the use of thromboprophylaxis.
Materials And Methods: A prospective study was conducted, including patients who underwent major elective surgical procedures. Demographic details were noted, and VTE prophylaxis offered if needed.
Purpose: Nowadays people are exposed to radiation due to various reasons, including natural, diagnostic, occupational or accidental exposure. High level of exposure to ionizing radiation can be fatal to human body. Synthetic drugs used to prevent radiation-induced damage are toxic in nature.
View Article and Find Full Text PDFValidated Stability-Indicating RP-HPLC Method for Daclatasvir in Tablets.
Turk J Pharm Sci
August 2023
Objectives: The current study goal was to create a precise, sensitive, and validated reverse phase-high performance liquid chromatography (RP-HPLC) method for assessing the direct-acting antiviral daclatasvir (DCV) as well as to evaluate the stability of DCV in both drug and tablet formulations. The current investigation was to display stability indicating methods under different stress conditions, including hydrolysis (acidic, basic, and neutral), oxidation, and photolysis.
Materials And Methods: All experiments were performed on HPLC Agilent 1100 with a stainless steel Hypersil C column having a particle size of 5 μm and a dimension of 4.
Importance: The BCG vaccine-used worldwide to prevent tuberculosis-confers multiple nonspecific beneficial effects, and intravesical BCG vaccine is currently the recommended treatment for non-muscle-invasive bladder cancer (NMIBC). Moreover, BCG vaccine has been hypothesized to reduce the risk of Alzheimer disease and related dementias (ADRD), but previous studies have been limited by sample size, study design, or analyses.
Objective: To evaluate whether intravesical BCG vaccine exposure is associated with a decreased incidence of ADRD in a cohort of patients with NMIBC while accounting for death as a competing event.