Publications by authors named "M Denos"
Article Synopsis
- This study investigates the impact of sex hormones, specifically estradiol, testosterone, and SHBG, on the risk of lung and colorectal cancers in women, with a focus on those of European ancestry.
- Using Mendelian randomization, the researchers analyzed data from genome-wide studies and health surveys to explore potential causal relationships.
- They found some indication that higher testosterone levels may lower the risk of certain lung cancers, but overall, there was no strong evidence linking sex hormones to the risk of lung or colorectal cancers.
Article Synopsis
- In medial temporal lobe epilepsy (MTLE), surgery can improve symptoms but may lead to memory decline, making it crucial to predict post-operative outcomes using fMRI tasks.
- A study of 46 MTLE patients assessed the effectiveness of fMRI language tasks in predicting memory outcomes after surgery; results showed memory fMRI had higher sensitivity in detecting hippocampal activity.
- Language fMRI, while less sensitive, provided better accuracy in predicting memory performance when hippocampal activation occurred, suggesting a need for combining both tasks to improve post-operative outcome predictions.
Limited studies have triangulated the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and systolic blood pressure (SBP), diastolic blood pressure (DBP) or hypertension risk utilizing both observational and Mendelian randomization (MR) approaches. We employed data from the Norwegian Trøndelag Health Study (HUNT) to conduct cross-sectional (n = 5854) and prospective (n = 3592) analyses, as well as one-sample MR (n = 86,324). We also used largest publicly available data for two-sample MR.
View Article and Find Full Text PDFThe roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies (GWASs) on sex hormones and from the Trøndelag Health (HUNT) Study and large consortia on cancers.
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