Publications by authors named "M Denholm"
Oncogenic transformation and Oct4, Sox2, Klf4 and c-Myc (OSKM)-mediated induction of pluripotency are two independent and incompatible cellular fates. While continuous expression of OSKM can convert normal somatic cells into teratogenic pluripotent cells, it remains speculative what is the impact of transient OSKM expression in cancer cells. Here, we find that OSKM expression limits the growth of transformed lung cells by inducing apoptosis and senescence.
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- The global population is aging, and cancer rates are increasing, leading to more older adults living with cancer and requiring specialized care.
- Recent advancements in oncology, such as earlier diagnosis and diverse treatment options, highlight the importance of preparing health services to effectively care for older cancer patients who often have complex needs.
- This paper reviews the significant progress made in the UK in providing comprehensive geriatric assessments and new clinical services for older cancer patients, aiming to share these improvements with other healthcare systems.
There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of senescent cells is one of the hallmarks of cancer, surprisingly little progress has been made in development of strategies for their detection in vivo.
View Article and Find Full Text PDFBackground: The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population.
Methods: In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020).
Palliative radiotherapy: survival prognostic factors - single-centre retrospective cohort study.
BMJ Support Palliat Care
February 2024
Objective: Patients with non-curative malignancy can receive palliative radiotherapy (PR) to alleviate symptoms. However, choosing the right patient to receive PR can be challenging, as some patients may not survive long enough to gain benefit. This study aims to identify prognostic factors for overall survival (OS) and 30-day mortality (30DM) following PR and to test these in a real-world cohort.
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