Control of Postharvest Green Mold in Citrus by the Antimicrobial Peptide BP15 and Its Lipopeptides.

This study examined the efficacy and mechanisms of action of the antimicrobial peptide BP15 and its lipopeptides, HBP15 and LBP15, against , the primary causative agent of green mold in citrus fruits. The findings revealed that all three antimicrobial peptides markedly inhibited the spore germination and mycelial growth of , with minimum inhibitory concentrations (MICs) of 3.12 μM for BP15, HBP15, and LBP15.

Deep Learning-Based Diagnosis Algorithm for Alzheimer's Disease.

Alzheimer's disease (AD), a degenerative condition affecting the central nervous system, has witnessed a notable rise in prevalence along with the increasing aging population. In recent years, the integration of cutting-edge medical imaging technologies with forefront theories in artificial intelligence has dramatically enhanced the efficiency of identifying and diagnosing brain diseases such as AD. This paper presents an innovative two-stage automatic auxiliary diagnosis algorithm for AD, based on an improved 3D DenseNet segmentation model and an improved MobileNetV3 classification model applied to brain MR images.

The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects.

Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite a notable decline in incidence in the United States and Western Europe over recent decades, the disease's persistence underscores the urgency for advanced research in its pathogenesis and treatment strategies. Central to this pursuit is the exploration of the mitogen-activated protein kinase (MAPK) pathway, a pivotal cellular mechanism implicated in the complex processes of gastric cancer development, including cellular proliferation, invasion, migration, and metastasis.

Chiglitazar diminishes the warburg effect through PPARγ/mTOR/PKM2 and increases the sensitivity of imatinib in chronic myeloid leukemia.

Background: A tyrosine kinase inhibitor (TKI) such as Imatinib (IM) is the preferred treatment for Chronic Myeloid Leukemia (CML). However, the emergence of IM resistance presents a significant challenge to disease management. A characteristic of cancer cells, including IM-resistant CMLs, are characterized by heightened uptake of glucose and aberrant glycolysis in the cytosol, which is known as the Warburg effect.

3D printing for controlled release Pharmaceuticals: Current trends and future directions.

In recent years, 3D printers have grown strongly in drug delivery and personalised medicine, being used more and more widely. In medicine, 3DP technology can advance personalised medicine and design dosage forms to regulate the drug release rate. This review gives an overview of the 3D printing for controlled-release pharmaceuticals, detailing the technical principles, common types (including extrusion, powder, liquid, and sheet lamination-based systems), drug release control mechanisms (e.