Publications by authors named "M Delva"
Article Synopsis
- The study investigates the link between motor subtypes of Parkinson's disease (PD) and the severity of depressive symptoms, suggesting that non-motor symptoms, particularly related to sleep, are critical to understanding patient disability.
- It involved 64 PD patients categorized into two groups: those with postural instability and gait disorder (PIGD) and those with other motor symptoms, using various assessment tools to measure sleep quality and mood.
- Results showed that PIGD patients experienced more severe depressive symptoms and poorer sleep quality, indicating that sleep issues could predict higher depression severity in PD patients.
Article Synopsis
- * Treatment options for neuropathic pain in MS include a mix of pharmacological strategies (like cannabinoids, muscle relaxants, anticonvulsants, antidepressants, and opioids) and non-pharmacological methods (such as physical therapy and psychotherapy).
- * Effective pain management in MS depends on factors like pain type and severity, patient preferences, and any existing health conditions, highlighting the need for improved strategies by healthcare professionals and researchers.
Hereditary spastic paraplegia is a genetically heterogeneous neurodegenerative disorder characterised primarily by muscle stiffness in the lower limbs. Neurodegenerative disorders are conditions that result from cellular and metabolic abnormalities, many of which have strong genetic ties. While ageing is a known contributor to these changes, certain neurodegenerative disorders can manifest early in life, progressively affecting a person's quality of life.
View Article and Find Full Text PDFBackground: Patients with multiple sclerosis (MS) are a high-risk group for neuropathic pain.
Objective: to investigate predictors of neuropathic dysesthetic pain (NDP) occurrence and chronification in patients with MS during a 2-year observation period.
Methods: After the exclusion criteria application and signing of informed consent, we recruited in the study 241 patients among which 23 patients prematurely stopped participating in the study.
Melanophilin is a myosin adaptor required for transporting the pigment melanin within cells. Loss of melanophilin in fish, birds, and mammals causes pigmentation defects, but little is known about the role of melanophilin in non-avian reptiles. Here we show that a frameshift in the melanophilin gene in ball python ( ) is associated with loss of pigment from shed skin.
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