Publications by authors named "M Delfini"
Article Synopsis
- - Uterine leiomyosarcomas (uLMS) are aggressive cancers that don't respond well to immune checkpoint blockade (ICB), and research indicates that issues with the PI3K/mTOR signaling pathway may contribute to this resistance.
- - A detailed analysis of 101 uLMS cases showed that over-activation of PI3K/mTOR is linked to immune evasion, with changes in the tumor microenvironment that limit immune responses.
- - By inhibiting the PI3K/mTOR pathway, researchers were able to change the tumor microenvironment, enhance anti-tumor immune responses, and improve the effectiveness of PD-1 blockade therapy, leading to better treatment outcomes in preclinical models.
Macrophages are innate immune cells that play key roles during both homeostasis and disease. Depending on the microenvironmental cues sensed in different tissues, macrophages are known to acquire specific phenotypes and exhibit unique features that, ultimately, orchestrate tissue homeostasis, defense, and repair. Within the tumor microenvironment, macrophages are referred to as tumor-associated macrophages (TAMs) and constitute a heterogeneous population.
View Article and Find Full Text PDFPecan nuts ( (Wangenh.) K. Koch) contain the highest number of phytochemicals of all nuts, are a natural source of unsaturated fatty acids and other nutrients and can be considered an important addition to the Mediterranean diet al.
View Article and Find Full Text PDFCorrect development and maturation of the enteric nervous system (ENS) is critical for survival. At birth, the ENS is immature and requires considerable refinement to exert its functions in adulthood. Here we demonstrate that resident macrophages of the muscularis externa (MMϕ) refine the ENS early in life by pruning synapses and phagocytosing enteric neurons.
View Article and Find Full Text PDFArticle Synopsis
- The research focuses on two Italian hazelnut varieties, 'Tonda Gentile Romana' and 'Tonda di Giffoni', which are recognized for their quality and are studied using Nuclear Magnetic Resonance (NMR) techniques to understand their unique seed structures.
- TD-NMR experiments identified that 'Tonda Gentile Romana' has five distinct relaxation components, while 'Tonda di Giffoni' has four, with specific components linked to lipid molecules and cytoplasmic water.
- Temperature changes during the experiments showed a surprising phase transition in the oil of the 'Tonda Gentile Romana', highlighting differences in matrix mobility and structure between the two cultivars.