Gastrin levels in patients with colorectal cancer.

Background/aims: In view of previous studies showing gastrin's trophic effects on tumor growth, the authors decided to investigate the relationship between fasting serum gastrin levels and the presence of colorectal carcinoma.

Methodology: Fifty-eight patients were studied: 19 controls who were blood bank donors, 19 patients with colorectal neoplasms, Dukes' Stage B or C, and 20 patients with advanced colorectal neoplasms (Dukes' Stage D). Pre-surgical and post-surgical serum gastrin levels were compared in patients with colorectal neoplasms (Dukes' Stage B or C).