Publications by authors named "M Del C Serradell"
Background: The diagnosis of isolated REM sleep behavior disorder (IRBD) requires video polysomnography (V-PSG) showing increased muscle activity and abnormal behaviors in REM sleep.
Objective: To describe in IRBD the behavioral manifestations occurring during REM sleep in the diagnostic V-PSG.
Methods: This is a systematic audiovisual V-PSG analysis of consecutive IRBD patients.
Isolated rapid-eye-movement sleep behavior disorder (iRBD) is a strong predictor of Parkinson's disease and Dementia with Lewy bodies. Previous studies indicate that cortical atrophy in iRBD patients may be linked to cognitive impairment, but the pattern of atrophy is inconsistently reported. This study aimed to elucidate cortical atrophy patterns in a cognitively unimpaired iRBD cohort, focusing on regions associated with cognitive functions, particularly the cuneus/precuneus, and evaluated the predictive value for future phenoconversion.
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- The study examines post-mortem brain tissues from individuals diagnosed with idiopathic REM sleep behavior disorder (IRBD) to investigate its potential link to neurodegenerative diseases, specifically focusing on signs of neuronal loss and the presence of key protein deposits.
- Researchers analyzed samples from 20 participants, most of whom were diagnosed with Lewy body disease, while a small number had Parkinson's disease-related conditions, revealing significant findings of neuronal damage associated with α-synuclein proteins, particularly in brain regions controlling REM sleep.
- While the sample size limited the statistical analysis, the outcomes suggest a strong correlation between IRBD and neurodegenerative diseases, emphasizing the importance of these pathological features for understanding the progression
Background And Purpose: Most patients with isolated rapid eye movement sleep behaviour disorder (iRBD) progress to a parkinsonian alpha-synucleinopathy. However, time to phenoconversion shows great variation. The aim of this study was to investigate whether cholinergic and dopaminergic dysfunction in iRBD patients was associated with impending phenoconversion.
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