Do Cementless, Collared Stems Prevent Aseptic Loosening, Subsidence, and Periprosthetic Fracture in Total Hip Arthroplasty?

Modern total hip arthroplasty (THA) is one of the most common and successful orthopedic procedures performed, utilizing a variety of fixation methods, stem geometry and designs to provide immediate post-operative weight bearing. The purpose of this study was to determine the incidence of intraoperative periprosthetic fractures, subsidence rates and aseptic loosening between collared stems compared with non-collared tapered stems during THA. A retrospective chart review identified 983 THA cases performed by a single surgeon between 2013-2021.

Effects of light regimes on circadian gene co-expression networks in .

Light/dark (LD) cycles are responsible for oscillations in gene expression, which modulate several aspects of plant physiology. Those oscillations can persist under constant conditions due to regulation by the circadian oscillator. The response of the transcriptome to light regimes is dynamic and allows plants to adapt rapidly to changing environmental conditions.

Decontamination of Actinide-contaminated Injured Skin with Ca-DTPA Products Using an Ex Vivo Rat Skin Model.

Skin contamination by α-emitting actinides such as plutonium and americium is a risk for workers during nuclear fuel production and reactor decommissioning. Decontamination of skin is an important medical countermeasure to limit potential internal contamination, particularly in the case of injured skin. Current recommendations include undressing of the victim followed by skin washing using soap or chelating agents, such as diethylene triamine pentaacetic acid (DTPA).

USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder.

The risk of developing drug addiction is strongly influenced by the epigenetic landscape and chromatin remodeling. While histone modifications such as methylation and acetylation have been studied in the ventral tegmental area and nucleus accumbens (NAc), the role of H2A monoubiquitination remains unknown. Our investigations, initially focused on the scaffold protein melanoma-associated antigen D1 (Maged1), reveal that H2A monoubiquitination in the paraventricular thalamus (PVT) significantly contributes to cocaine-adaptive behaviors and transcriptional repression induced by cocaine.