Publications by authors named "M Decoster"
Following traumatic brain injury (TBI), secondary brain damage due to chronic inflammation is the most predominant cause of the delayed onset of mood and memory disorders. Currently no therapeutic approach is available to effectively mitigate secondary brain injury after TBI. One reason is the blood-brain barrier (BBB), which prevents the passage of most therapeutic agents into the brain.
View Article and Find Full Text PDFCopper-cystine-based high aspect ratio structures (CuHARS) possess exceptional physical and chemical properties and exhibit remarkable biodegradability in human physiological conditions. Extensive testing has confirmed the biocompatibility and biodegradability of CuHARS under diverse biological conditions, making them a viable source of essential Cu. These ions are vital for catalyzing the production of nitric oxide (NO) from the decomposition of S-nitrosothiols (RSNOs) found in human blood.
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- Alzheimer's Disease (AD) leads to various symptoms like memory loss and cognitive decline, prompting a review of new therapies including Aducanumab, the first FDA-approved drug targeting amyloid plaques in the brain.
- Other drugs like lecanemab are also discussed, along with therapies like active and passive immunotherapy, and various vaccines currently in clinical trials.
- The review covers a wide range of interventions for AD, including approved drugs, ongoing clinical and pre-clinical trials, off-label medications, and non-pharmacological approaches, highlighting both promising developments and remaining challenges.
Objectives: To investigate the characteristics and trends of out-of-hospital attention-deficit/hyperactivity disorder (ADHD) medication-related therapeutic errors among youth <20 years old reported to US poison centers.
Methods: National Poison Data System data from 2000 through 2021 were analyzed. Population-based rates were calculated using US census data.
The NASA Double Asteroid Redirection Test (DART) mission performed a kinetic impact on asteroid Dimorphos, the satellite of the binary asteroid (65803) Didymos, at 23:14 UTC on 26 September 2022 as a planetary defence test. DART was the first hypervelocity impact experiment on an asteroid at size and velocity scales relevant to planetary defence, intended to validate kinetic impact as a means of asteroid deflection. Here we report a determination of the momentum transferred to an asteroid by kinetic impact.
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