Publications by authors named "M Dean"
To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We determined the HPV type and analyzed the expression of 51 genes. HPV31 was significantly more prevalent in precancer than stage 1 cancer and invasive cancer (p < 0.
View Article and Find Full Text PDFArticle Synopsis
- - Parents with BRCA1/2 mutations face challenges in sharing their genetic risk information with their minor children, including uncertainty about timing, content, and approach.
- - A scoping review analyzed 22 articles exploring strategies for parents and healthcare professionals regarding these conversations but found a lack of support interventions for parents during the disclosure process.
- - The study highlights a need for healthcare professionals to create effective communication strategies and emphasizes the necessity for further research on how families navigate sharing genetic information.
Article Synopsis
- This study investigates the effects of continuing osimertinib alongside platinum-pemetrexed chemotherapy for patients with EGFR mutant non-small cell lung cancer (NSCLC) who have had disease progression on osimertinib.
- It analyzed data from 159 eligible patients out of 421 identified, comparing outcomes between two groups: one continuing osimertinib with chemotherapy and the other receiving chemotherapy alone.
- Results showed that the group continuing osimertinib experienced a significant improvement in progression-free survival (9.0 months vs. 4.5 months), indicating a potential clinical benefit in this treatment strategy.
Tessellations (surface architectures of arrays of hard tiles) are common in natural and man-made designs. Boxfishes (Ostracioidea) are almost completely encased in a tessellated armor and have evolved a plethora of cross-sectional carapace shapes, yet whether the scutes constructing these exhibit comparable variation is unknown. Using high-resolution microCT and semi-automatic segmentation algorithms, we quantitatively examined thousands of scutes from 13 species of diverse body form.
View Article and Find Full Text PDFBackground And Objectives: Leucoreduction is used to remove donor leucocytes during red blood cell (RBC) manufacture. However, not all are removed, and long-term survival of donor leucocytes, termed transfusion-associated microchimerism (TAM), has been shown to occur in some patients following RBC transfusion. The mechanism of TAM occurrence is unknown.
View Article and Find Full Text PDF