Publications by authors named "M De Robertis"
Objective: Posterior Interbody fusion can be associated to adjacent segment disease (ASD) some years after surgery. The aim of this study is to confirm the rate of ASD in isthmic spondylolisthesis treated by posterior fusion.
Methods: Patients treated by posterior lumbar fusion were collected between January 2014 to June 2022.
Gene electrotransfer (GET) has recently emerged as an effective nonviral approach for plasmid DNA (pDNA) delivery in gene therapy for several pathologies, including cancer. Multiple mechanisms have been identified that influence cell biology after GET, as electroporation significantly increases pDNA uptake and immunogenicity, which may directly influence target cell death. However, the molecular effects of electroporation-mediated DNA delivery have yet to be fully elucidated.
View Article and Find Full Text PDFBackground: Congenital craniovertebral junction anomalies (CCVJAs) encompass a diverse range of conditions characterized by distorted anatomy and significant variation in the pathways of neurovascular structures. This study aims to assess the safety and feasibility of tailoring posterior fixation for CCVJAs through intraoperative CT-based navigation.
Methods: An in-depth retrospective analysis was conducted on eight patients diagnosed with CCVJAs (excluding Arnold-Chiari malformation).
Article Synopsis
- The study compares the effectiveness of two surgical approaches for treating mobile spine chordomas: en bloc resection versus intralesional resection with adjuvant hadron therapy, focusing on local control (LC) and overall survival (OS).
- In the analysis of 33 patients, no significant differences in LC between the two methods were found, but certain pre-operative factors like pathologic fractures were linked to a higher risk of local recurrence (LR).
- Although en bloc resection is preferred for better outcomes, advances in hadron therapy provide a viable alternative for local control with manageable side effects when using intralesional surgery.
Article Synopsis
- - The development of neurosurgical guidelines has grown increasingly complex, posing challenges in their application due to varying methodologies and limited high-quality evidence.
- - This mini review focuses on guidelines published since 1996, emphasizing the reliance on a few randomized controlled trials (RCTs) and the lag in timely updates, which complicates their relevance in clinical practice.
- - To improve global applicability, especially in low- and middle-income countries, there's a call for increased inclusivity in guideline authorship and consideration of alternatives like consensus conferences for addressing these challenges.