Publications by authors named "M De Petrini"
Periodontitis is a prevalent inflammatory disease affecting the supporting structures of the teeth, leading to gum recession, tooth loss, and systemic health complications. Traditional diagnostic methods and treatments, such as clinical evaluation and scaling, often fall short in early detection and targeted therapy, particularly in complex or advanced cases. Recent advancements in nanomedicine offer promising solutions for improving both the diagnosis and treatment of periodontitis.
View Article and Find Full Text PDFObjectives: This systematic review aimed to analyse the published evidence for the use of non-invasive methods for the early detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs).
Methods: The literature was systematically searched through several databases: PubMed, Cochrane Library, and Web of Science. Additional exploration was performed through cross-checks on the bibliographies of selected reviews.
The interaction between oral bacteria and dental implant surfaces is a critical factor in the success and longevity of dental implants. With advancements in additive manufacturing technologies, selective laser melting (SLM) has emerged as a prominent method for producing titanium implants with highly controlled microstructures and porosities. These 3D printed titanium surfaces offer significant benefits, such as enhanced osseointegration and improved mechanical properties.
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- Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, typically treated with surgery followed by radiotherapy and temozolomide; a trial is assessing the addition of Dendritic Cell vaccination (DCvax) to standard therapy.* ! -
- The study is a phase II trial involving 9 patients, focusing on progression-free survival (PFS) and safety, with DCvax administered after standard treatment and showing promising early immune response results.* ! -
- Initial findings indicate that the combination therapy is well-tolerated and achieves the initial study endpoints, allowing enrollment of additional patients to continue the research.* !
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinically representative post-infarction left ventricular (LV) dysfunction model remains unclear. We, therefore, investigated the safety and efficacy of recombinant human (rh)PlGF-2 in the infarcted porcine heart in a randomized, placebo-controlled blinded study. We induced myocardial infarction (MI) in pigs using 75 min mid-LAD balloon occlusion followed by reperfusion.
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