Publications by authors named "M De Leo"

Objective: To investigate the association between family adversities in childhood and depression in three follow-up visits of a cohort of Brazilian adults.

Methods: A total of 12,636 participants from the Longitudinal Study of Adult Health (ELSA-Brasil), who attended three interview/examination visits (2008-2010, 2012-2014, and 2017-2019), were included. Five family dysfunctions and the childhood family dysfunction score (0, 1, and 2+ dysfunctions) were used.

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Purpose: We developed an electronic patient-facing family history collection tool including B-RST 3.0, PREMM risk assessments and "limited family knowledge/structure" information designed for primary care settings. We evaluated the tool's performance compared with genetic-counselor-collected information for clinical risk stratification in a population with barriers to access.

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Article Synopsis
  • * The ST2/IL-33 pathway promotes immune tolerance by expanding regulatory T cells but also triggers proinflammatory cytokine production for immune defense and tissue repair.
  • * Researchers developed improved ST2 inhibitors that effectively reduced ST2 upregulation and IL-1β release in human mast cells, suggesting potential for treating diseases mediated by mast cells.
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Introduction: Parents of children with additional needs experience compromised physical and mental health and higher stress, and their ability to engage in meaningful occupations is impacted by their additional caregiving tasks. Online interventions targeting mental health, stress, and well-being for parents of children with additional needs have potential to increase supports alongside occupational therapy direct services. The aims of this review are to systematically identify and synthesise evidence of effectiveness of online interventions aimed at improving mental health, stress, and well-being of parents of children with additional needs.

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  • Canine mast cell tumors (MCTs) have a mutated form of the KIT tyrosine kinase receptor, which is linked to abnormal growth of mast cells.
  • The study aimed to evaluate how different KIT immunohistochemical expression patterns affect the survival of dogs treated with tyrosine kinase inhibitors after surgery.
  • Results suggest that KIT's abnormal distribution might indicate reduced effectiveness of these inhibitors, offering valuable insight into treatment outcomes for canine MCTs.
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