Iron Accumulation and Lipid Peroxidation in Cellular Models of Nemaline Myopathies.

One of the most prevalent types of congenital myopathy is nemaline myopathy (NM), which is recognized by histopathological examination of muscle fibers for the presence of "nemaline bodies" (rods). Mutations in the actin alpha 1 () and nebulin () genes result in the most prevalent types of NM. Muscle weakness and hypotonia are the main clinical characteristics of this disease.

Exploring How Neighborhood Environment Perceptions Moderate the Health Benefits of Movement Behaviors Among Latinos in Los Angeles.

Purpose: This study examined how the potential health benefits of movement behaviors - physical activity (PA), sedentary time, and sleep - vary by neighborhood perceptions among Latinos.

Design: Cross-sectional analysis of baseline data from churchgoing Latino adults participating in an ongoing randomized controlled trial to promote PA.

Setting: East Los Angeles, California, and surrounding neighborhoods.

Gender-transformative HIV and SRHR programme approaches for adolescents and young people: a realist review to inform policy and programmes.

Introduction: Gender inequalities continue to drive new HIV and sexually transmitted infections (STIs) at rates too high to achieve global goals. In high HIV-burden jurisdictions, this is particularly true for adolescent girls and young women at disproportionate risk, while social and systemic barriers also impede the engagement of young men and gender minorities with health services. We sought evidence of approaches to promote sexual and reproductive health (SRH) outcomes by addressing gender transformation and removing structural barriers that broadly limit prospects for adolescents and young people.

Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma.

Background: Transarterial chemoembolization (TACE) is the first-line therapeutic option for patients with intermediate-stage hepatocellular carcinoma (HCC). Tumor neovascularization allows tumor growth and may facilitate the release of circulating tumor cells (CTCs) to the bloodstream after TACE. We investigated the relationship between early release of CTCs and radiological response after TACE.