Publications by authors named "M De Frias"
Pathogenic variants of cause Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by axonal degeneration. GDAP1, an atypical glutathione S-transferase, localizes to the outer mitochondrial membrane (OMM), regulating this organelle's dynamics, transport, and membrane contact sites (MCSs). It has been proposed that GDAP1 functions as a cellular redox sensor.
View Article and Find Full Text PDFDifferential insertion of arginine in saturated and unsaturated lipid vesicles.
Biochim Biophys Acta Biomembr
December 2024
Article Synopsis
- This study investigates how L-Arginine (L-Arg) affects lipid membranes using various techniques like fluorescence spectroscopy and dynamic light scattering.
- L-Arg reduces the polarizability of saturated lipids, leading to an increase in vesicle size, while in unsaturated lipids, it increases polarizability without significantly changing size.
- The interaction of L-Arg differs based on whether the lipids are saturated or unsaturated, and cholesterol appears to dampen these effects.
Objective: To evaluate the association between the expanded lymphoid profile and inborn errors of immunity using flow cytometry.
Methods: Observational and cross-sectional, case-control study, carried out in patients with a diagnosis or clinical suspicion of inborn errors of immunity, treated at the Santísima Trinidad Children's Hospital in Córdoba, Argentina, from August 2021 to November 2022. Clinical data were collected, and peripheral blood samples were obtained for flow cytometry analysis, using the PIDOT tube, to identify lymphocyte subpopulations.
Impact of Nonalcoholic Fatty Liver Disease on the Survival of People Living With HIV.
Aliment Pharmacol Ther
February 2025
Background: Nonalcoholic fatty liver disease (NAFLD) is an increasing concern for people living with HIV (PLWH). However, information on the impact of NAFLD on the prognosis of PLWH is very scarce.
Aims: To investigate the influence of NAFLD on the overall and liver-related mortality in PLWH.
The present work investigates the impact of particle size reduction of traditional ceramic materials as partial substitutes for Portland cement in mortars. Ceramic brick, ceramic tile, and stoneware were selected, with three particle sizes ( of 1, 5, and 15 μm) achieved through grinding operations adapted to each material grindability. The reactivity of ceramic powders was assessed via dissolution in saturated lime solution.
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