Publications by authors named "M De Felice"
An aberrant pro-inflammatory microglia response has been associated with most neurodegenerative disorders. Identifying microglia druggable checkpoints to restore their physiological functions is an emerging challenge. Recent data have shown that microglia produce de novo neurosteroids, endogenous molecules exerting potent anti-inflammatory activity.
View Article and Find Full Text PDFObjective: ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations represent fundamental predictive biomarkers for advanced non-small cell lung cancer (NSCLC) patients to ensure the best treatment choice. In this scenario, RNA-based NGS approach has emerged as an extremely useful tool for detecting these alterations. In this study, we report our NGS molecular records on ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations detected by using a narrow RNA-based NGS panel, namely SiRe fusion.
View Article and Find Full Text PDFActivity budget investigations are necessary to understand how individuals within a group manage their daily activities, thus providing insights into the social dynamics of a species. Our objective was to explore and describe the behavioral activities within a group of managed care killer whales. From 261 hours of coded surface video collected from April 2022 to January 2023, we scan-sampled day-time hours to examine eight behavioral categories exhibited by 8-9 killer whales bimonthly.
View Article and Find Full Text PDFHigh-dose methotrexate is an effective and safe therapy. It is included in the treatment regimens of various hematologic and oncologic diseases. The acute and severe toxicity of this chemotherapeutic agent is unusual.
View Article and Find Full Text PDFArticle Synopsis
- - Gastric cancer (GC) is a complex and aggressive type of cancer that starts in the stomach and can spread to other organs, often becoming deadly by stage IV.
- - The study analyzed gene expression data from 719 patients to identify a specific gene signature linked to the progression from stage I to stage IV GC, focusing on factors like ECM organization and epithelial-to-mesenchymal transition (EMT).
- - The findings suggest that this gene signature could help identify stage I patients at higher risk of progression, potentially aiding in early treatment strategies, while also providing a new experimental model to study how gastric cancer spreads.