Publications by authors named "M De Bruycker"
Purpose: This meta-analysis evaluates the mid- to long-term survival outcome of MAT (meniscal allograft transplantation). Potential prognosticators, with particular focus on chondral status and age of the patient at the time of transplantation, were also analysed.
Study Design: Meta-analysis.
Antibiotic use in a district hospital in Kabul, Afghanistan: are we overprescribing?
Public Health Action
December 2014
Setting: A district hospital in Kabul, Afghanistan, supported by Médecins Sans Frontières (MSF).
Objectives: To assess antibiotic prescribing practices in the out-patient department in summer (August 2013) and winter (January 2014).
Design: Cross-sectional study, using routinely collected hospital data and using World Health Organization (WHO) defined daily dose (DDD) methodology.
Setting: A rural paediatric hospital in Bo, Sierra Leone.
Objectives: To assess the level of adherence to standard treatment guidelines among clinicians prescribing treatment for children admitted with a diagnosis of malaria and/or lower respiratory tract infection (LRTI), and determine the association between (non) adherence and hospital outcomes, given that non-rational use of medicines is a serious global problem.
Design: Secondary analysis of routine programme data.
Article Synopsis
- Peroxisomal 3-ketoacyl-CoA thiolase B (Thb) plays a crucial role in β-oxidation of fatty acids in peroxisomes and is activated by the nuclear hormone receptor PPARα through the compound Wy14,643 (Wy).
- Mice lacking Thb showed reduced peroxisomal β-oxidation when treated with Wy, while mitochondrial β-oxidation remained unaffected, indicating Thb's specific role in fatty acid metabolism.
- The absence of Thb led to a failure to upregulate cholesterol biosynthesis genes in response to Wy, suggesting Thb's involvement in cholesterol regulation and highlighting the potential of targeting peroxisomes for treating cholesterol imbalances in
Defects in the formation of the cerebral cortex and the cerebellum are a prominent feature of the peroxisome biogenesis disorder Zellweger syndrome and in mouse models for this disease. The aim of the present study was to investigate the impact of liver and brain peroxisomes on neurodevelopment by analyzing mice with tissue-selective elimination of peroxisomes. To this end, Pex5-loxP mice were bred with albumin/alpha-fetoprotein (Alfp)-Cre and nestin (Nes)-Cre mice.
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