Publications by authors named "M De Biasi"
Metabolic-epigenetic interactions are emerging as key pathways in regulating alcohol-related transcriptional changes in the brain. Recently, we have shown that this is mediated by the metabolic enzyme Acetyl-CoA synthetase 2 (Acss2), which is nuclear and chromatin-bound in neurons. Mice lacking ACSS2 fail to deposit alcohol-derived acetate onto histones in the brain and show no conditioned place preference for ethanol reward.
View Article and Find Full Text PDFSmoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.
Shyamala K Venkatesh Bethany L Stangl Jia Yan Natalia A Quijano Cardé Elliot A Stein Mariella De Biasi
Int J Neuropsychopharmacol
October 2024
Article Synopsis
- Alcohol and nicotine interact with the nicotinic acetylcholine receptor system, influencing reward responses and leading to increased co-use and misuse of these substances.
- A specific genetic variation (rs16969968) in the CHRNA5 gene is strongly linked to nicotine effects, but its role in alcohol consumption is less understood.
- In a study with 980 participants, smokers reported higher alcohol use, and those with the GG genotype consumed more alcohol than those with the AA/AG genotypes, suggesting that this genetic variant may partly protect against alcohol misuse by influencing negative expectations about drinking.