Publications by authors named "M De Beule"
Background: Device-related thrombosis (DRT) occurs in up to 4% of patients undergoing left atrial appendage occlusion (LAAO) and is associated with substantial morbidity and mortality. However, its pathophysiology, predictors, and optimal management remain unclear.
Objectives: This study aims to assess flow dynamic factors correlating to DRT.
Article Synopsis
- * Four patients experienced CO, while five were at high risk and five had no risk; simulations showed that those with CO had shorter distances between their coronary ostia and the closest structures compared to the others.
- * The findings suggest that patient-specific simulations can help assess the risk of CO before TAVR, potentially improving patient outcomes through better preoperative planning.
Understanding the role of the left atrial appendage on the flow in the atrium.
Catheter Cardiovasc Interv
November 2024
Article Synopsis
- The study investigates the impact of excluding the left atrial appendage (LAA) on blood flow dynamics in patients with atrial fibrillation, who are at risk of stroke and bleeding.
- Computational fluid dynamics simulations were performed for nine patients, analyzing various flow parameters before and after LAA exclusion.
- Results indicated a significant decrease in Time Averaged Wall Shear Stress and low-magnitude velocities, alongside slight increases in Oscillatory Shear Index, Relative Residence Time, and pressure; further research is needed to understand the clinical significance of these changes.
Background: Three-dimensional transesophageal echocardiography (3D-TEE) is the primary imaging tool for left atrial appendage closure planning. The utility of cardiac computed tomography angiography (CCTA) and patient-specific computational models is unknown.
Objectives: The purpose of this study was to evaluate the accuracy of the FEops HEARTguide patient-specific computational modeling in predicting appropriate device size, location, and compression of the WATCHMAN FLX compared to intraprocedural 3D-TEE.
We sought to assess the amount and distribution of force on the valve frame after transcatheter aortic valve replacement (TAVR) via patient-specific computer simulation. Patients successfully treated with the self-expanding Venus A-Valve and multislice computed tomography (MSCT) pre- and post-TAVR were retrospectively included. Patient-specific finite element models of the aortic root and prosthesis were constructed.
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