Publications by authors named "M Dari"
Long non-coding RNAs (lncRNAs) play vital roles in the development and progression of various tumors through multiple mechanisms. Among these, HOTTIP (HOXA transcript at the distal tip) stands out as an intriguing candidate with diverse functions in several malignancies, including breast cancer and gynecologic cancers such as ovarian, cervical, and endometrial cancers, which are significant global health concerns. HOTTIP interacts with key signaling pathways associated with these cancers, including Wnt/β-catenin, PI3K/AKT, and MEK/ERK pathways, enhancing their activation and downstream effects.
View Article and Find Full Text PDFOvarian cancer (OC) is a gynecologic disease characterized by the uncontrolled growth and proliferation of abnormal cells in the ovaries, fallopian tubes, or peritoneum. Emerging evidence has shown the pivotal role of non-coding RNAs (ncRNAs), such as miRNAs, in driving the pathogenesis of OC. miRNAs are recognized as small ncRNAs that play critical roles in regulating gene expression in normal development and in disease states, including OC.
View Article and Find Full Text PDFMicroRNAs (miRNAs) have emerged as important regulators of gene expression in various biological processes, including cancer. miR-182-5p has gained attention for its potential implications in gynecologic cancers, including breast, ovarian, endometrial, and cervical cancers. miR-182-5p dysregulation has been associated with multiple facets of tumor biology in gynecologic cancers, including tumor initiation, progression, metastasis, and therapeutic response.
View Article and Find Full Text PDFArticle Synopsis
- - Osteomas are the most frequent benign tumors found in the sinonasal area and are often discovered incidentally during unrelated imaging studies; larger versions over 30 mm are termed "giant" osteomas and can lead to complications if they invade nearby spaces.
- - This report details a case involving a 30-year-old woman with a 45 mm fronto-ethmoidal osteoma causing pressure on her eye and frontal lobe, requiring a specialized surgical team of ENT and neurosurgeons for treatment.
- - The goal of treating giant sinonasal osteomas is complete surgical removal through a combined approach, and while the risk of recurrence exists, outcomes can vary based on the surgical methods used.
Breast cancer is a prevalent and aggressive disease characterized by high metastasis, recurrence, and mortality rates. While cisplatin is an effective chemotherapy drug, its use is limited by its toxic effects on the body. Despite advancements in therapeutic strategies, the therapeutic response is often unsatisfactory due to drug resistance, leading to poor prognosis.
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