Adipose Mesenchymal Stem Cell Exosomes Regulate Ferroptosis via ATF3 to Attenuate Acute Myocardial Infarction.

Objective: During acute myocardial infarction (AMI), ferroptosis occurs in cardiomyocytes, leading to ventricular remodeling. To investigate the influence of exosomes (Exo) derived from adipose mesenchymal stem cells (AD-MSCs) on cardiomyocytes, a therapeutic approach to resolve AMI may be discovered.

Methods: The Exo of AD-MSCs was isolated and identified, and internalized into cardiomyocytes.

Hordeum I genome unlocks adaptive evolution and genetic potential for crop improvement.

Crop wild relatives (CWRs) are invaluable for crop improvement. Among these, Hordeum I-genome species exhibit exceptional tolerance to alkali and salt stresses. Here we present a chromosome-scale genome assembly of Hordeum brevisubulatum (II, 2n = 2x =14) and genome resequencing of 38 diploid germplasms spanning 7 I-genome species.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

Multi-Omics Analysis Revealed the Molecular Mechanisms Affecting Average Daily Gain in Cattle.

The average daily gain (ADG) is a critical index for evaluating growth rates in cattle and is closely linked to the economic benefits of the cattle industry. Heredity is one of the factors affecting the daily gain of cattle. However, the molecular mechanisms regulating ADG remain incompletely understood.

Comprehensive SHAP Values and Single-Cell Sequencing Technology Reveal Key Cell Clusters in Bovine Skeletal Muscle.

The skeletal muscle of cattle is the main component of their muscular system, responsible for supporting and movement functions. However, there are still many unknown areas regarding the ranking of the importance of different types of cell populations within it. This study conducted in-depth research and made a series of significant findings.