Publications by authors named "M Dalla Zorza"
Article Synopsis
- Colorectal cancer (CRC) is linked to factors like obesity and inflammation, which may disrupt immune response by accumulating foam cells (FC) in tumors, potentially impacting cancer progression.*
- The study involved analyzing tumor samples from CRC patients to investigate the relationship between FC and immune cell dynamics, highlighting the presence of reduced CD8 T cells and increased regulatory T cells in tumors with high FC accumulation.*
- Results indicated that higher levels of FC are associated with worse outcomes, including lower disease-free survival rates in CRC, and in vitro experiments showed that FC suppress CD8 T cell activity through mechanisms involving TGF-β.*
Article Synopsis
- Sporadic desmoid fibromatosis (DF) is a rare and aggressive tumor linked to mutations in the CTNNB1 gene, with standard treatment being active surveillance, although 30% may require additional therapy due to unpredictable disease progression.
- In a study involving 56 patients, the researchers analyzed both tumor biopsies and plasma samples to assess the presence and quantity of circulating tumor DNA (ctDNA) correlating to CTNNB1 mutations, finding varying detection rates for different mutations.
- The findings suggest a potential role for ctDNA as a diagnostic tool to monitor disease progression, warranting further clinical trials to determine its effectiveness as a predictive biomarker in managing sporadic DF.
Study Question: Can traceability of gametes and embryos be ensured during IVF?
Summary Answer: The use of a simple and comprehensive traceability system that includes the most susceptible phases during the IVF process minimizes the risk of mismatches.
What Is Known Already: Mismatches in IVF are very rare but unfortunately possible with dramatic consequences for both patients and health care professionals. Traceability is thus a fundamental aspect of the treatment.
Traceability of cells during IVF is a fundamental aspect of treatment, and involves witnessing protocols. Failure mode and effects analysis (FMEA) is a method of identifying real or potential breakdowns in processes, and allows strategies to mitigate risks to be developed. To examine the risks associated with witnessing protocols, an FMEA was carried out in a busy IVF centre, before and after implementation of an electronic witnessing system (EWS).
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