From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy.

The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a vital role in maintaining genomic stability and regulating cellular responses to stress. Dysregulation of p53 is frequently observed in hematological malignancies, significantly impacting disease progression and patient outcomes. This review aims to examine the regulatory mechanisms of p53, the implications of TP53 mutations in various hematological cancers, and emerging therapeutic strategies targeting p53.

Enhancing Ultradeep Hydrodesulfurization of Coker Diesel through Adsorptive Predenitrogenation.

The petroleum refining industry places significant challenge in the production of ultralow-sulfur diesel (ULSD) from various middle distillates with high nitrogen concentration in an energy-efficient and cost-effective way to meet strict environmental regulations as coexisting nitrogen compounds significantly inhibit the ultradeep hydrodesulfurization (HDS). Among all of the approaches reported in the literature for this challenge, a combination of adsorptive denitrogenation (ADN) and HDS has attracted great attention. This study focuses on ultradeep HDS of coker diesel (CD) through a synergistic approach combining ADN over a carbon-based adsorbent and the current HDS process.

Investigating the Effects of Simultaneous Administration of Melatonin and Atorvastatin against High Glucose-Induced Oxidative Stress and Apoptosis in Cultured Chondrocytes.

Objective: Osteoarthritis (OA) is a prevalent joint disorder categorized into phenotypic subtypes, including those associated with age, traumatic events, and metabolic syndrome. In the aging population, type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) frequently coexist. This can result in higher rates of disability and a greater financial burden.

A 360° Approach to Patient Care in Aesthetic Facial Rejuvenation.

Background: Aesthetic medicine has traditionally focused on addressing perceived problem areas, with lack of long-term planning and engagement.

Objectives: This article describes a patient-centric model for nonsurgical aesthetic medical practice, termed the 360° approach to facial aesthetic rejuvenation.

Methods: The 360° approach was divided into 4 foundational pillars.

CDC27 gene expression patterns as a potential biomarker in Acute Leukemia.

Background: Treating Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) is difficult due to high relapse rates and drug resistance. Tumorigenesis is largely dependent on disruption of the cell cycle progression. While the role of Cell Division Cycle 27 (CDC27) in the anaphase-promoting complex/cyclosome is well-known, its significance in the pathophysiology of acute leukemia and its potential as a biomarker are less well understood.