Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower-risk myelodysplastic syndromes.

Lower risk (LR) myelodysplastic syndromes (MDS) are heterogeneous hematopoietic stem and progenitor disorders caused by the accumulation of somatic mutations in various genes including epigenetic regulators that may produce convergent DNA methylation patterns driving specific gene expression profiles. The integration of genomic, epigenomic, and transcriptomic profiling has the potential to spotlight distinct LR-MDS categories on the basis of pathophysiological mechanisms. We performed a comprehensive study of somatic mutations and DNA methylation in a large and clinically well-annotated cohort of treatment-naive patients with LR-MDS at diagnosis from the EUMDS registry (ClinicalTrials.

Medical researchers' perception of sharing of metadata from case report forms.

Introduction: Publishing medical metadata stored in case report forms (CRFs) is a prerequisite for the development of a learning health system (LHS) by fostering reuse of metadata and standardization in health research. The aim of our study was to investigate medical researchers' (MRs) willingness to share CRFs, to identify reasons for and against CRF sharing, and to determine if and under which conditions MRs might consider sharing CRF metadata via a public registry.

Methods: We examined CRF data sharing commitments for 1842 interventional trials registered on the German Clinical Trials Registry (DRKS) from January 1, 2020, to December 31, 2021.

Correction: Bouchard et al. A Multisite Non-Inferiority Randomized Controlled Trial of the Efficacy of Cognitive-Behavior Therapy for Generalized Anxiety Disorder Delivered by Videoconference. 2022, , 5924.

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Socioeconomic and demographic factors influencing interpersonal communication between patients with chronic conditions and family physicians: A systematic review.

Objective: This systematic review assessed the socioeconomic and demographic factors influencing interpersonal communication between family physicians and patients with chronic diseases.

Methods: We searched three databases (Embase, MEDLINE, and Cochrane) for published empirical studies reporting interpersonal communication between adults with chronic conditions and their family physicians. Gender, sex, race or ethnicity, low levels of literacy and/or health knowledge, and lower level of education or income were the factors of interest.

Accelerated Testing of PEI-Silica Sorbent Pellets for Direct Air Capture.

Amine-based sorbents have shown exceptional CO uptake for direct air capture (DAC). However, amine degradation is a major issue for this class of materials, hindering their deployment for large-scale DAC. In this study, a comprehensive evaluation of polyethylenimine (PEI) sorbents was conducted to understand their degradation under process-relevant environments for the DAC of CO.