Publications by authors named "M DENIS"

Purpose: Prelingual deaf children with cochlear implants show lower digit span test scores compared to normal-hearing peers, suggesting a working memory impairment. To pinpoint more precisely the subprocesses responsible for this impairment, we designed a sequence reproduction task with varying length (two to six stimuli), modality (auditory or visual), and compressibility (sequences with more or less regular patterns). Results on 22 school-age children with cochlear implants and 21 normal-hearing children revealed a deficit of children with cochlear implants only in the auditory modality.

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  • - A novel method for creating substituted pyridines from iodoenones is introduced, using a two-step process that includes Sonogashira coupling with a free alkyne.
  • - The process involves a sequence of chemical reactions, including thiophenol treatment and a Michael-retro-Michael process, leading to the final pyridine structure.
  • - This technique allows for the incorporation of various substituents at different positions on the pyridine ring, expanding possibilities for synthesizing bioactive heterocycles.
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  • HSCT is a potentially curative treatment for blood and immune diseases but often involves harmful chemotherapy or radiation, leading to serious side effects like infections and secondary cancers.
  • Research has shown that using targeted monoclonal antibodies (mAbs) against αCD117 can offer a safer alternative for HSCT preparations, with promising results in SCID mouse models.
  • The study identifies that the ACK2 mAb effectively inhibits HSC proliferation and enhances engraftment after HSCT, and when combined with the αCD47 mAb, it significantly improves outcomes in wildtype mouse models.
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Raw milk is considered a high-risk source of Campylobacter due to faecal contamination from healthy cattle and farm environments, thus linking raw milk consumption to global outbreaks. Detection of Campylobacter in raw milk poses challenges due to low contamination levels and antibacterial properties of the milk. Culture-based protocols for Campylobacter detection in milk vary, mainly with regard to pH adjustment and the choice of enrichment broth.

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miRNAs constitute fine-tuners of gene expression and are implicated in a variety of diseases spanning from inflammation to cancer. miRNA expression is deregulated in rheumatoid arthritis (RA); however, their specific role in key arthritogenic cells such as the synovial fibroblast (SF) remains elusive. Previous studies have shown that expression is upregulated in RA SFs.

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