Publications by authors named "M D Zeidler"

Article Synopsis
  • Placebo effects are often seen in clinical trials for benzodiazepine receptor agonists, leading to recommendations for discontinuation of these medications in older adults and the use of cognitive behavioral therapy for insomnia (CBTI) instead.
  • This study aims to compare the effects of a masked tapering process combined with enhanced CBTI against standard CBTI with an unmasked taper in helping older adults discontinue benzodiazepine receptor agonists.
  • The primary outcome measured is the percentage of participants successfully discontinuing their medication after 6 months, with additional assessments of insomnia severity and short-term discontinuation rates.
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Background: Poor memory for treatment is associated with poorer treatment adherence and poorer patient outcomes. The memory support intervention (MSI) was developed to improve patient memory for treatment with the goal of improving patient outcomes. The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether a new, streamlined, and potent version of the MSI improves outcomes for midlife and older adults.

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Bilberry ( L.) expansion in subalpine and alpine ecosystems is increasing due to climate change and reduced land management. This review examines bilberry traits, environmental responses, and ecosystem impacts.

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Article Synopsis
  • Positive airway pressure (PAP) therapy is the standard treatment for obstructive sleep apnea (OSA), but many patients struggle to consistently use it; understanding their blood oxygen levels may help improve adherence.
  • This study investigates the feasibility and effectiveness of a program (mPAP) that integrates data from consumer wearable devices with PAP usage reports to enhance patient self-management of therapy.
  • The trial will involve 50 veterans with OSA who will be split into intervention and control groups to assess how well wearable device feedback influences their PAP usage over a 28-day period.
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Background And Objectives: Patch-Clamp recordings allow for in depth electrophysiological characterization of single cells, their general biophysical properties as well as characteristics of voltage- and ligand-gated ionic currents. Different acquisition modes, such as whole-cell patch-clamp recordings in the current or voltage clamp configuration, capacitance measurements or single channel recordings from cultured cells as well as acute brain slices are routinely performed for these purposes. Nevertheless, multipurpose transparent and adaptable software tools to perform reproducible state-of-the-art analysis of multiple experiment types and to manage larger sets of experimental data are currently unavailable.

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