Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia.

Background: Incompatibility between parental platelet (PLT) antigens may lead to sensitization of mother and development of fetal and neonatal alloimmune thrombocytopenia (FNAIT) resulting in fetal thrombocytopenia. Intravenous immunoglobulin (IVIG) with or without prednisone is the most effective, evidence-based antenatal treatment for subsequent FNAIT-affected pregnancies. IVIG infusion causes hemolysis in other settings, the degree depending upon patient blood groups (BGs).

Omission of fetal sampling in treatment of subsequent pregnancies in fetal-neonatal alloimmune thrombocytopenia.

Background: Fetal-neonatal alloimmune thrombocytopenia affects approximately 1 of 1000 live births, most of which are not severely thrombocytopenic. Despite effective treatment with intravenous gammaglobulin and/or prednisone, antenatal management of a subsequent affected pregnancy is complicated by the risks associated with fetal blood sampling. Furthermore, there are no biomarker(s) of high risk other than the occurrence of intracranial hemorrhage in a previous sibling.

Linear and nonlinear optical characterization of aluminum nanoantennas.

We experimentally determine the order of multiphoton induced luminescence of aluminum nanoantennas fabricated on a nonconductive substrate using electron-beam lithography to be 2.11 (±0.10).

Investigating the influences of the precise manufactured shape of dipole nanoantennas on their optical properties.

Fabrication of small nanoantennas with high aspect ratios via electron beam lithography is at the current technical limit of nanofabrication and hence significant deviations from the intended shape of small nanobars occur. Via numerical simulations, we investigate the influence of geometrical variations of gap nanoantennas, having dimensions on the order of only a few tens of nanometers. We show that those deviations have a significant influence on the performance of such nanoantennas.