Publications by authors named "M D Vlad"
Colistin resistance poses a significant clinical challenge, particularly in Gram-negative bacteria. This study investigates the occurrence of plasmid-mediated colistin resistance among isolates (, , and spp.) and non-fermentative rods ( and ).
View Article and Find Full Text PDFThe Use of Kidney Biomarkers, Nephrin and KIM-1, for the Detection of Early Glomerular and Tubular Damage in Patients with Acromegaly: A Case-Control Pilot Study.
Diseases
September 2024
Article Synopsis
- Acromegaly is a rare disorder that results from excessive growth hormone from a pituitary tumor, potentially leading to kidney issues, diabetes, and hypertension.
- A case-control study compared 23 acromegalic patients to 21 healthy individuals, measuring various kidney function parameters like serum creatinine and urinary albumin/creatinine ratio.
- Results showed acromegalic patients had higher urinary albumin/creatinine ratios and lower estimated glomerular filtration rates, but no signs of kidney damage were detected through biomarkers like nephrin and KIM-1, suggesting more research is needed for early kidney involvement detection.
Article Synopsis
- - Graves' disease (GD) is an autoimmune condition that impacts the thyroid, potentially leading to hyperthyroidism and other complications, but recent studies indicate it may also increase the risk of thyroid cancer, especially differentiated thyroid carcinomas and, less frequently, medullary thyroid carcinoma (MTC).
- - A case series highlighted three female patients with GD who were diagnosed with MTC, all showing concerning thyroid nodules and elevated calcitonin levels, ultimately requiring total thyroid removal, with histology confirming MTC.
- - The study emphasizes the need for routine calcitonin screening in GD patients to ensure early detection of thyroid cancers and recommends this testing be included in standard diagnostic procedures for those with thyroid abnormalities.
In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases.
View Article and Find Full Text PDFBackground: This study explores patient acceptance of influenza vaccination administered by pharmacists in Romania during the 2023 season, considering it a novel strategy to address gaps in knowledge. Pharmacy-based vaccination deviates from traditional methods, providing high-risk patients with full reimbursement and others with 50% reimbursement, allowing a choice between family doctors and pharmacies for vaccine administration.
Material And Method: The survey includes 15 questions covering socio-demographic data, health information, vaccination preferences, and perceptions of pharmacy-based vaccinations.