Higher Versus Lower Protein Delivery in Critically Ill Patients: A Systematic Review and Bayesian Meta-Analysis.

Objectives: Recent multicenter trials suggest that higher protein delivery may result in worse outcomes in critically ill patients, but uncertainty remains. An updated Bayesian meta-analysis of recent evidence was conducted to estimate the probabilities of beneficial and harmful treatment effects.

Data Sources: An updated systematic search was performed in three databases until September 4, 2024.

Sleep spindle variation in patients with Parkinson's disease on first nights of sub-optimal deep brain stimulation.

Objective: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a common treatment for motor symptoms of Parkinson's disease but its influence on non-motor symptoms is less clear. Sleep spindles are known to be reduced in patients with Parkinson's disease, but the effect of STN DBS is unknown. The objective of our study was to address this knowledge gap.

Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis.

BACKGROUNDWhile most hypertriglyceridemia is asymptomatic, hypertriglyceridemia-associated acute pancreatitis (HTG-AP) can be more severe than AP of other etiologies. The reasons underlying this are unclear. We thus examined whether lipolytic generation of nonesterified fatty acids (NEFAs) from circulating triglycerides (TGs) could worsen clinical outcomes.

The geometry of correlated variability leads to highly suboptimal discriminative sensory coding.

The brain represents the world through the activity of neural populations; however, whether the computational goal of sensory coding is to support discrimination of sensory stimuli or to generate an internal model of the sensory world is unclear. Correlated variability across a neural population (noise correlations) is commonly observed experimentally, and many studies demonstrate that correlated variability improves discriminative sensory coding compared to a null model with no correlations. However, such results do not address whether correlated variability is for discriminative sensory coding.

Identifying standardised neuropsychological test measures sensitive to cannabis consumption: A systematic review.

Background: While numerous studies have indicated acute neurocognitive changes following the administration of Δ9-tetrahydrocannabinol (THC; the psychoactive component of cannabis), the standardised neuropsychological tests most sensitive to THC are yet to be identified. As such, this systematic review analysed scientific evidence (since 2000) on the effects of THC on standardised neuropsychological test measures.

Methods: This review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.