Faecal immunochemical tests for patients with symptoms suggestive of colorectal cancer: An updated systematic review and multiple-threshold meta-analysis of diagnostic test accuracy studies.

Aim: Extending faecal immunochemical tests for haemoglobin (FIT) to all primary care patients with symptoms suggestive of colorectal cancer (CRC) could identify people who are likely to benefit from colonoscopy and facilitate earlier treatment. The aim of this work was to investigate the diagnostic accuracy of FIT across different analysers at different thresholds, as a single test or in duplicate (dual FIT).

Method: This systematic review and meta-analysis searched 10 sources (December 2022).

The FAIR database: facilitating access to public health research literature.

Objectives: In public health, access to research literature is critical to informing decision-making and to identify knowledge gaps. However, identifying relevant research is not a straightforward task since public health interventions are often complex, can have positive and negative impacts on health inequalities and are applied in diverse and rapidly evolving settings. We developed a "living" database of public health research literature to facilitate access to this information using Natural Language Processing tools.

Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.

Importance: For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.

Objective: To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.

Design, Setting, And Participants: A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.

Prevalence of feline upper respiratory tract pathogens and risk factors for clinical disease and final outcomes in an RSPCA shelter in Queensland, Australia.

Introduction: Feline respiratory tract infection poses a serious challenge in animal shelters. Potential risk factors include pathogens introduced through animals entering the shelter. We aimed to determine the proportion of animals shedding feline upper respiratory tract (URT) pathogens at the time of entry and to assess how this contributed to the burden of clinical disease and final outcomes.

Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.

Gene expression in individual neurons can change during development to adulthood and can have large effects on behavior. Additionally, the insulin/insulin-like signaling (IIS) pathway regulates many of the adult functions of Caenorhabditis elegans, including learning and memory, via transcriptional changes. We used the deep resolution of single-nucleus RNA sequencing to define the adult transcriptome of each neuron in wild-type and daf-2 mutants, revealing expression differences between L4 larval and adult neurons in chemoreceptors, synaptic genes, and learning/memory genes.