Formulation Optimization and Characterization of Tizanidine Hydrochloride-Loaded Gold Nanoparticles Using Quality by Design Approach.

Background: Gold nanoparticles (GNP) have been used extensively in cancer biologics and as drug carrier systems for improved pharmacokinetics and effective therapeutic action. GNPs also ensure reliable diagnosis with sensitive imaging.

Objective: This study aimed to synthesize tizanidine hydrochloride (TZN)-biodegradable gold (Au) nanoparticles by the reduction of chloroauric acid (HAuCl4) with trisodium citrate using a microwave synthesizer and quality by design approach.

Layer-by-Layer Immobilization of DNA Aptamers on Ag-Incorporated Co-Succinate Metal-Organic Framework for Hg(II) Detection.

Layer-by-layer (LbL) immobilization of DNA aptamers in the realm of electrochemical detection of heavy metal ions (HMIs) offers an enhancement in specificity, sensitivity, and low detection limits by leveraging the cross-reactivity obtained from multiple interactions between immobilized aptamers and developed material surfaces. In this research, we present a LbL approach for the immobilization of thiol- and amino-modified DNA aptamers on a Ag-incorporated cobalt-succinate metal-organic framework (MOF) (Ag@Co-Succinate) to achieve a cross-reactive effect on the electrochemical behavior of the sensor. The solvothermal method was utilized to synthesize Ag@Co-Succinate, which was also characterized through various techniques to elucidate its structure, morphology, and presence of functional groups, confirming its suitability as a host matrix for immobilizing both aptamers.

Effect of thermal annealing on an emissive layer containing a blend of a small molecule and polymer as host for application in OLEDs.

In order to improve the performance of OLEDs, a host-guest mixture was used as an emissive layer. To have better host properties, a mixture of different materials with suitable properties can also be used as a host. In this study, we used a mixture of a polymer and a small molecule as the host and studied the effect of thermal annealing on the emissive layer properties by using Ir(ppy) as the emitter.

High sensitivity carbon monoxide detector using iron tetraphenyl porphyrin functionalized reduced graphene oxide.

The detection of pollutant and toxic gases has attracted extensive attention due to the growing environmental issues. In the present investigation, free-based tetraphenyl porphyrin (TPP) and iron tetraphenyl porphyrin (FeTPP) are used to functionalize thermally reduced graphene oxide (rGO) and further used for the detection of carbon monoxide (CO). TPP and FeTPP functionalized rGO (FeTPP@rGO) sensors are fabricated on a glass substrate with thermally coated copper electrodes.

Microwave-Assisted Coprecipitation Synthesis and Local Structural Investigation on NiO, β-Ni(OH)/CoO Nanosheets, and CoO Nanorods Using X-ray Absorption Spectroscopy at Co-Ni K-edge and Synchrotron X-ray Diffraction.

Developing the most straightforward, cheapest, and eco-friendly approaches for synthesizing nanostructures with well-defined morphology having the highest possible surface area to volume ratio is challenging for design and process. In the present work, nanosheets of NiO and β-Ni(OH)/CoO, and nanorods of CoO have been synthesized at a large scale via the microwave-assisted chemical coprecipitation method under low temperature and atmospheric pressure. X-ray absorption spectroscopy (XAS) measurements, which comprises both X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) techniques, have been carried out at Co and Ni K-edges to probe the electronic structure of the samples.