Publications by authors named "M D Santos-Rubio"
Objective: We aimed to evaluate the use of CDK4/6 inhibitors as a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in a cohort of patients with metastatic breast cancer treated with denosumab.
Methods: This was a multicentre, retrospective, observational study. All patients with breast cancer treated with denosumab (January 2011-December 2022) were included.
Objectives: Trifluridine-tipiracil (TAS-102), an oral cytotoxic agent used in adult patients with refractory metastatic colorectal cancer (mCRC), has been associated with neutropenia (chemotherapy-induced neutropenia) (CIN)).
Materials And Methods: We evaluated the efficacy and safety of TAS-102 in a group of 45 mCRC patients (median age 66 years) in Huelva province, Spain, in a retrospective, multicenter observational study.
Results: We showed that the association between TAS-102 and CIN can be used as a predictor of efficacy.
Article Synopsis
- The study aimed to evaluate the effects of patient selection criteria in a telepharmacy program and analyze socioeconomic factors affecting requests for this service.
- Researchers conducted a retrospective study comparing telepharmacy application data before and after implementing these criteria to assess trends in requests, user numbers, and reasons for application rejections.
- Findings indicated that while telepharmacy usage increased, socio-economic factors like average income impacted request frequency, with lower-income patients utilizing telepharmacy more frequently, and criteria adjustments led to broader access regardless of location or financial status.
Hereditary transthyretin amyloidosis (hATTR) is an ultra-rare illness. Inotersen is a 2'-O-methoxyethyl (2'MOE)-modified antisense oligonucleotides (ASO) approved in 2018 as a polyneuropathy treatment for adults with hereditary transthyretin amyloidosis stages 1 or 2. Inotersen can produce grade 4 thrombocytopenia as a severe adverse reaction that can lead to potentially fatal hemorrhage complications.
View Article and Find Full Text PDFObjective: The aim of the study was to evaluate the concordance among 10 anticholinergic scales for the measurement of anticholinergic drug exposure in at-risk elderly complex chronic patients in primary care.
Methods: An 8-month cross-sectional, multicenter study was carried out in a cohort of complex chronic patients older than 65 years in treatment with at least 1 drug with anticholinergic activity. Demographic, pharmacological, and clinical data were collected.