Robust control of a compliant manipulator with reduced dynamics and sliding perturbation observer.

Compliant manipulators equipped with Variable Stiffness Actuation (VSA) possess the ability to safely interact with their environment and adapt to complex tasks. However, the tracking performance of such manipulators is significantly influenced by their intrinsic compliance and varying stiffness. This paper presents a robust control strategy for compliant manipulators equipped with Discrete Variable Stiffness Actuation (DVSA), aimed at enhancing tracking performance under both fixed and varying stiffness conditions.

The Global Influenza Hospital Surveillance Network: A Multicountry Public Health Collaboration.

Respiratory viruses represent a significant public health threat. There is the need for robust and coordinated surveillance to guide global health responses. Established in 2012, the Global Influenza Hospital Surveillance Network (GIHSN) addresses this need by collecting clinical and virological data on persons with acute respiratory illnesses across a network of hospitals worldwide.

Economic burden of antimicrobial resistance on patients in Pakistan.

Background: Antimicrobial resistance (AMR) occurs when microbes undergo changes that render antimicrobial drugs ineffective against them, resulting in limited, more expensive treatment options, longer hospital stays, and increased mortality rates. No study has estimated the costs related to AMR in hospitals in Pakistan. This study was conducted to determine the financial burden of antimicrobial resistance (AMR) in Pakistan and to compare it with the additional costs incurred by patients who respond well to antimicrobial treatments.

Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome.

Background: Aicardi-Goutières syndrome (AGS) is a rare monogenic type I interferonopathy characterized by dysregulated inflammation and tissue damage that primarily affects the central nervous system. AGS is genetically diverse, with pathogenic variants across multiple genes, including TREX1, which drives excessive type I interferon (IFN) production.

Objective: This study investigated the genetic and molecular mechanisms underlying AGS in a family of two affected children, focusing on the role of variants in protein expression and dysregulation of the interferon pathway.

Trends and regional variations in chronic ischemic heart disease and lung cancer-related mortality among American adults: Insights from retrospective CDC wonder analysis.

Introduction: Lung cancer remains the leading cause of cancer-related mortality in the United States and shares cardiovascular risk factors with chronic ischemic heart disease (CIHD). However, the cumulative mortality burden of these comorbid conditions is underexplored. This study aims to retrospectively assess mortality trends among American adults with concurrent lung cancer and CIHD.