A real-world study to assess the disease control of moderate to severe atopic dermatitis in patients receiving dupilumab therapy, with atopic dermatitis control tool in Gulf countries.

Purpose/aim Of The Study: There is limited real-world evidence regarding the effectiveness and safety of dupilumab in Gulf countries. The study aimed to evaluate atopic dermatitis (AD) disease control in adult and adolescent patients (≥12 years) treated with dupilumab in Gulf countries.

Materials And Methods: This observational study included patients with moderate-to-severe AD who initiated dupilumab within 30 days.

Comparison between relining of ill-fitted maxillary complete denture versus CAD/CAM milling of new one regarding patient satisfaction, denture retention and adaptation.

Purpose: This study aimed to compare different treatment modalities to correct ill-fitted maxillary complete denture either by the conventional relining method or by scanning the relining impression and digitally construct a new denture regarding patient satisfaction, denture retention, and adaptation.

Materials And Methods: Twelve edentulous patients suffering from loose maxillary complete dentures were selected, dentures' borders and fitting surfaces were prepared, and relining impressions were taken, the impressions were scanned and the STL files were used for CAD/CAM milling ( computer aided designing/ computer aided manufacturing) of new maxillary dentures (Group A), then the relining impression went through the conventional laboratory steps to fabricate (Group B) maxillary dentures. Both groups were evaluated regarding patient satisfaction by a specially designed questionnaire, retention values were measured by a digital force gauge at denture insertion appointment and two weeks later, geomagic software was used to evaluate dentures adaptation to oral tissues.

Synthesis, in vivo evaluation, and in silico molecular docking of benzo[h]quinoline derivatives as potential Culex pipiens L. larvicides.

A new series of benzo[h]quinoline-containing heterocycles was synthesized via reactions of benzo[h]quinolinyl-2(3H)-furanone with some nitrogen bidentate nucleophiles, leading to the formation of pyridazinone, pyrrolinone, benzimidazole, and benzoxazinone derivatives. The synthesized compounds were evaluated for their insecticidal activity against Culex pipiens L. larvae.

Demystifying furan formation in foods: Implications for human health, detection, and control measures: A review.

Furan (C₄H₄O), an unintended hazardous compound, is formed in various thermally processed foods through multiple pathways, raising concerns due to its potential carcinogenicity in humans. The aim of this comprehensive review was to synthesize and evaluate the latest research on furan, from its formation by different precursors to its presence in diverse food matrices, as well as the emerging methods for its detection and mitigation. Emphasizing the toxicity of furan, it explored evidence from in vitro and in vivo studies, including reproductive toxicity, carcinogenic effects, and related biomarkers.