Publications by authors named "M D Posthumus"
Joint laxity is a multifactorial phenotype with a heritable component. Mutations or common polymorphisms within the α1(V) () α1(XI) () and α2(XI) () collagen genes have been reported or proposed to associate with joint hypermobility, range of motion and/or genu recurvatum. The aim of this study was to investigate whether polymorphisms within these collagen-encoding genes are associated with measurements of knee joint laxity and computed ligament length changes within the non-dominant leg.
View Article and Find Full Text PDFBackground: Joint laxity is a multifactorial phenotype with a heritable component. Type I collagen gene (COL1A1) mutations cause connective tissue disorders with joint hypermobility as a clinical feature, while variants within COL1A1 and type III collagen gene (COL3A1) are associated with musculoskeletal injuries. The aim of this study was to investigate whether COL1A1 and COL3A1 variants are associated with measurements of non-dominant knee joint laxity and computed ligament length changes.
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- Diagnosing giant cell arteritis (GCA) is challenging due to its non-specific symptoms, especially when patients also show signs of polymyalgia rheumatica (PMR); common markers like CRP and ESR are ineffective in distinguishing between them.
- * The study analyzed serum/plasma levels of 12 biomarkers in treatment-naïve GCA patients from two cohorts to identify reliable indicators for GCA.
- * Findings suggest that specific biomarkers, particularly the angiopoietin-2/-1 ratios and MMP-3 levels, can help differentiate GCA from PMR and infections, potentially guiding further diagnostic actions for at-risk patients.
Article Synopsis
- Researchers studied genetic variations in VEGFA and KDR and their link to ACL injury risk using samples from Sweden, Poland, and Australia.
- The rs2010963 CC genotype of the VEGFA gene was found to significantly increase ACL injury risk, while certain haplotypes (A-A-G and A-G-G) were underrepresented in ACL patients, suggesting a protective effect.
- Overall, the study supports a connection between specific genetic markers in VEGFA and the risk of ACL injuries, emphasizing the role of vascular regulation in ligament health.
Effect of Anti-Rheumatic Treatment on the Periodontal Condition of Rheumatoid Arthritis Patients.
Int J Environ Res Public Health
March 2021
Periodontitis, a bacterial-induced infection of the supporting soft and hard tissues of the teeth (the periodontium), is common in patients with rheumatoid arthritis (RA). As RA and periodontitis underlie common inflammatory pathways, targeting the progression of RA might mediate both periodontitis and RA. On the other hand, patients with RA on immunosuppressive medication have an increased risk of infection.
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