Publications by authors named "M D Paull"
Article Synopsis
- Pediatric long COVID is still not fully understood, and this study aimed to explore its impact on children and adolescents following the 2021 Delta variant outbreak in Australia.
- Out of 11,864 surveyed parents, 17.6% responded, with 11.7% of children reporting ongoing symptoms or functional impairment; only a small fraction were classified as having Long COVID.
- The findings suggest that while most children recover within 12 weeks, a notable minority may experience long-term symptoms, highlighting the need for further attention and research on risk factors like age and previous health issues.
Antigen presentation defects in tumors are prevalent mechanisms of adaptive immune evasion and resistance to cancer immunotherapy, whereas how tumors evade innate immunity is less clear. Using CRISPR screens, we discovered that IGSF8 expressed on tumors suppresses NK cell function by interacting with human KIR3DL2 and mouse Klra9 receptors on NK cells. IGSF8 is normally expressed in neuronal tissues and is not required for cell survival in vitro or in vivo.
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- Achondroplasia (ACH) is a common genetic condition leading to disproportionate short stature, caused by mutations in the FGFR3 gene, affecting bone growth.
- A mouse model of ACH was treated with infigratinib, a selective FGFR inhibitor, at lower doses (0.2 and 0.5 mg/kg daily, and 1 mg/kg every 3 days), showing significant improvements in bone growth and skeletal development over 15 days.
- The study confirmed that infigratinib enhanced chondrocyte differentiation and helped alleviate complications like foramen magnum stenosis, suggesting its potential as a safe therapeutic option for children with ACH.
This paper examines myths and misconceptions about university student volunteering. Our study explored the experiences of students, host organisations and universities participating in volunteering in Australia, identify good practice, and discover barriers to success. A qualitative approach involved 60 semi-structured interviews with stakeholders.
View Article and Find Full Text PDFMapping antibody binding using multiplexed epitope substitution analysis.
J Immunol Methods
December 2021
A more complete understanding of antibody epitopes would aid the development of diagnostics, therapeutic antibodies, and vaccines. However, current methods for mapping antibody binding to epitopes require a targeted experimental approach, which limits throughput. To address these limitations, we developed Multiplexed Epitope Substitution Analysis (MESA) which can rapidly characterize various distinct epitopes using millions of antibody-binding peptides.
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