Publications by authors named "M D Osuna"
Background: Venous thromboembolic events have been reported in persons with hemophilia A who received emicizumab and activated prothrombin complex concentrate (APCC) concomitantly, but the relevant mechanism(s) remains unclear. We speculated that activated protein C (APC) and antithrombin (AT) resistance might be associated with these adverse events.
Objectives: To investigate APC and AT resistance in factor (F)VIII-deficient (FVIIIdef) plasma in the presence of emicizumab and APCC.
Article Synopsis
- The patient received multiple doses of rFVIIa around the time of surgery, and there were no bleeding or thrombotic complications reported during and after the operation.
- The study suggests that using rFVIIa every 8 hours may be effective for managing bleeding risks in patients treated with emicizumab during surgery.
Article Synopsis
- - Diamond-Blackfan anemia syndrome (DBAS) is a genetic disorder affecting bone marrow, often seen in infants, leading to low red blood cell counts and growth issues in about half of those affected.
- - The condition results from a deficiency in one of 24 ribosomal protein genes, with mutations in RPS19 responsible for about 25% of cases.
- - Researchers created induced pluripotent stem cell (iPSC) lines from two patients with different RPS19 mutations and also developed isogenic lines by correcting the mutations using a gene-editing technique called Cas9-mediated homology directed repair.
White mustard, (Sinapis alba), a problematic broadleaf weed in many Mediterranean countries in arable fields has been detected as resistant to tribenuron-methyl in Tunisia. Greenhouse and laboratory studies were conducted to characterize Target-Site Resistance (TSR) and the Non-Target Site Resistance (NTSR) mechanisms in two suspected white mustard biotypes. Herbicide dose-response experiments confirmed that the two S.
View Article and Find Full Text PDFPain Lowers Subjective Survival Probabilities Among Middle-Aged and Older Adults.
J Gerontol B Psychol Sci Soc Sci
July 2024
Objectives: Pain is a leading cause of disability and a limiting factor in individuals' assessments of their own subjective health; however, its association with subjective longevity has yet to be explored. Subjective survival probabilities (SSPs), or one's own perceived chances of living to a given age, can influence individuals' behavior as they plan for their futures. This study assesses whether pain correlates to lower SSPs.
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