Clients' Experiences and Satisfaction with an Integrated Intensive Outpatient Program for Substance Use Disorders.

Background: Comorbidity between substance use disorders and other mental health conditions is common, yet existing treatments often fail to address its full spectrum. Opportunities for integrated treatment are limited, and the effects of such treatment remain relatively unexplored. This study explores the experiences of individuals with substance use disorders who successfully completed a four-month integrated intensive program at an outpatient addiction-care clinic in western Sweden.

Mobile Electronic Patient-Reported Outcomes and Interactive Support During Breast and Prostate Cancer Treatment: Health Economic Evaluation From Two Randomized Controlled Trials.

Background: Digital interventions for supportive care during cancer treatment incorporating electronic patient-reported outcomes (ePROs) can enhance early detection of symptoms and facilitate timely symptom management. However, economic evaluations are needed.

Objective: This study aims to conduct a cost-utility analysis of an app for ePRO and interactive support from the perspective of the payer (Region Stockholm Health Care Organization) and to explore its impact on patient health care utilization and costs.

Continuous map of early hematopoietic stem cell differentiation across human lifetime.

Uncovering early gene network changes of human hematopoietic stem cells (HSCs) leading to differentiation induction is of utmost importance for therapeutic manipulation. We employed single cell proteo-transcriptomic sequencing to FACS-enriched bone marrow hematopoietic stem and progenitor cells (HSPCs) from 15 healthy donors. Pseudotime analysis reveals four major differentiation trajectories, which remain consistent upon aging, with an early branching point into megakaryocyte-erythroid progenitors.

How does pole length affect lower back muscle activity at different inclines and skiing intensities during double poling?

Purpose: This study aimed to investigate how pole length, incline, and skiing intensity affect lower back muscle activation in elite cross-country skiers. This addressing a critical gap in understanding the biomechanical demands and risk of low back pain of double poling (DP).

Method: Eleven elite cross-country skiers performed skiing trials on a treadmill, varying in incline (flat vs.