The frequency of complications in a cohort of patients diagnosed with hemophilia A and hemophilia B receiving prophylactic treatment in Colombia: A retrospective noninterventional study.

Introduction: Hemophilia A and B are disorders associated with the deficit of coagulation factors VIII and IX.

Objective: Was to determine the incidence of complications in a cohort of patients diagnosed with moderate and severe hemophilia A or B under treatment in a specialized institution.

Methods: A retrospective study of a cohort of patients with replacement therapy for hemophilia A or B, evaluating treatment and complications between January/2012 and July/2019.

Pump-probe measurement of metastable state lifetime reduced by cooperative upconversion in a high-concentration erbium-doped fiber.

We report measurements of the metastable state lifetime in a high-concentration erbium-doped fiber. We use a single-wavelength pump-probe technique that allows us to measure the average lifetime over the entire fiber length. A reduction in the lifetime of approximately 20% caused by a cooperative upconversion effect is clearly observed when the input power is increased up to 10 mW.