Publications by authors named "M D Mira Quiros"
Fast and efficient galvanostatic conversion of 2,4-diarylfurans into dimeric furan-2(5)-ones is now possible in one pot and good yields at room temperature in sustainable aqueous organic solvent. Recent applications of these highly desired structures demand our attention since they are a versatile alternative to acrylates in polymerization to achieve green materials. The reaction mechanism proposal, supported by density functional theory (DFT) theoretical calculations, involves furanoxy radicals, detected by electron paramagnetic resonance (EPR), as the last intermediate before a homocoupling step that affords butenolides.
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- Spatial transcriptomics (ST) technologies allow for in-depth gene expression analysis at a very fine scale, but traditional methods face challenges due to complex tissue structures and irregular cell shapes.
- The new method, FICTURE, offers a segmentation-free approach that can analyze large-scale transcriptome data with submicron precision, making it compatible with different types of ST data.
- FICTURE is significantly more efficient than existing methods and improves our understanding of intricate tissue architectures in challenging areas like vascular and fibrotic tissues, enhancing the exploration of high-resolution spatial transcriptomics.
Turgor is the driving force of plant growth, making it possible for roots to overcome soil resistance or for stems to counteract gravity. Maintaining a constant growth rate while avoiding cell content dilution, which would progressively stop the inward water flux, imposes the production or import of osmolytes in proportion to the increase of volume. We coin this phenomenon stationary osmoregulation.
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- Interferon-gamma (IFNγ) has a dual role in intestinal inflammation, being known for its pro-inflammatory effects while also promoting repair by boosting TNFα receptor 2 expression in intestinal epithelial cells.
- Research indicates that IFNγ signals through the transcription factor STAT1 to enhance TNFR2 expression after cell injury, both in lab settings and live models.
- The study reveals that neutralizing IFNγ after intestinal injury hinders healing, suggesting that the timing and levels of IFNγ and TNFα are crucial for restoring tissue balance, challenging the idea that all pro-inflammatory agents only cause harm.
Thrombospondin-1 (TSP1) is a matricellular protein associated with the regulation of cell migration through direct binding interactions with integrin proteins and by associating with other receptors known to regulate integrin function, including CD47 and CD36. We previously demonstrated that deletion of an epithelial TSP1 receptor, CD47, attenuates epithelial wound repair following intestinal mucosal injury. However, the mechanisms by which TSP1 contributes to intestinal mucosal repair remain poorly understood.
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