Cutaneous Manifestations of Langerhans Cell Histiocytosis in Pediatric Age: A Case Report.

Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplastic disorder that mainly affects the skin and bones, with dermatological manifestations that can be easily confused with other dermatological conditions, such as seborrheic eczema, psoriasis, lesions of herpes simplex virus infection, fungal infection, lichen planus, and cutaneous lymphomas. This case report describes an eight-month-old infant who, at a child health appointment, presented with progressive erythematous papulovesicular lesions, initially treated with hygiene measures (skin hydration and hygiene) and mupirocin ointment, but which persisted and worsened, leading to a skin biopsy. The diagnosis of self-limiting congenital histiocytosis was confirmed, and the child was referred to the Portuguese Oncology Institute.

From breast cancer diagnosis to survivorship: Analyzing perioperative biopsychosocial phenotypes and their relationship to pain on long term.

Persistent breast cancer treatment-related pain affects up to 40% of patients, decreasing their quality of life (QoL). While current research typically utilizes correlation and regression analysis to identify biopsychosocial phenotypes contributing to this pain, this study employs cluster analysis to identify qualitatively different phenotypes based on somatosensory and psychosocial characteristics both before and one week post-breast cancer surgery. Further, it investigates how these phenotypes are related to pain intensity one year post-surgery and examines the evolution of phenotype membership from pre- to post-surgery.

Mapping of quantitative trait loci (QTL) in L. for tolerance to water stress.

L. plants are sensitive to water stress conditions throughout their life cycle from seed germination to seed setting. This study aims at identifying quantitative trait loci (QTL) linked to tolerance to water stress mimicked by applications of 10% polyethylene glycol-6000 (PEG-6000).