Risk factors for severe adverse drug reactions in hospitalized patients.

Background: Severe adverse drug reactions (sADRs) are becoming increasingly common nowadays. The incidence of sADRs is approaching 6.7%, and the incidence of fatal adverse reactions is 0.

Serious adverse effects of selected antiseizure medications used for treatment of focal onset seizures.

Introduction: The third-generation antiseizure medications used for the treatment of focal seizures, lacosamide, eslicarbazepine acetate, perampanel, brivaracetam, and cenobamate, may elicit serious adverse reactions which could be preventable if a prescriber is acquainted with the risk factors.

Areas Covered: The literature search was conducted in MEDLINE, SCOPUS, and EBSCO databases, without time and language restrictions. Only clinical studies, observational human studies, case reports, and case series that reported serious adverse drug reactions and risk factors were considered.

Pain management in hidradenitis suppurativa.

Pain is the most impactful symptom in hidradenitis suppurativa (HS), contributing to physical limitations, worsened mental health, and impaired social relationships. Some HS-directed therapies ameliorate HS pain; however, these medications provide insufficient relief for many people living with HS. This article reviews what is currently known about HS pain phenotypes and pathophysiology, the effectiveness of HS treatments for pain, and practical suggestions for dermatologists to help patients manage the symptoms of acute and chronic HS pain.

Population pharmacokinetics of meropenem in critically ill patients.

Objective: The pharmacokinetics of meropenem are significantly altered in critically ill patients. A population pharmacokinetic study was designed to estimate typical values of meropenem clearance in critically ill patients and evaluate potential factors of influence.

Methods: After meropenem reached a steady state in each patient, two blood samples were taken within the dose interval.

Revisions of the and species groups of the genus Meigen, 1803 (Diptera, Syrphidae).

This study focuses on the lineage within the genus , exploring morphological, genetic, and distributional aspects of two related assemblies within this lineage: the and species groups. An integrative taxonomic approach was followed to ensure comprehensive species identification and validation, using adult morphology, wing geometric morphometrics, and genetic analysis of the mtDNA COI gene. In the group, seven species were identified, including three new species: Vujić, Radenković & Likov, , Vujić, Radenković & Likov, , and Vujić, Radenković & Likov, In the group, our revision revealed a new species, Vujić, Radenković & Likov, , and the revalidation of Gil Collado, 1929, Macquart, 1842 is redescribed.