Publications by authors named "M D Lopez-Leon"
High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics to analyze human tissue samples at different stages of HGSOC development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), and invasive HGSOC.
View Article and Find Full Text PDFArticle Synopsis
- Recent advances in next generation sequencing (NGS) have improved our understanding of non-coding tandem repeat DNA, especially in studying hybrid zones where different biological entities meet.
- The study focused on two grasshopper subspecies in the Pyrenees, where 152 tandem repeat sequences were identified, and 77 families were mapped using fluorescent in situ hybridization (FISH).
- Findings indicated 50 of these TR families are useful as hybrid zone markers, revealing that TR bands were unevenly distributed and showing signs of introgression consistent with earlier studies.
Background: The full catalog of satellite DNA (satDNA) within a same genome constitutes the satellitome. The Library Hypothesis predicts that satDNA in relative species reflects that in their common ancestor, but the evolutionary mechanisms and pathways of satDNA evolution have never been analyzed for full satellitomes. We compare here the satellitomes of two Oedipodine grasshoppers (Locusta migratoria and Oedaleus decorus) which shared their most recent common ancestor about 22.
View Article and Find Full Text PDFSatellite DNA Is an Inseparable Fellow Traveler of B Chromosomes.
Prog Mol Subcell Biol
September 2021
Article Synopsis
- Next-Generation Sequencing (NGS) shows that B chromosomes in some species have a lot of special repeating DNA called satellite DNA (satDNA).
- Scientists are trying to figure out if this satDNA is important for how B chromosomes work, or if it just ends up there because of how B chromosomes act.
- In a study of 16 species, 38% had unique satDNAs specific to B chromosomes, but only one had a B chromosome from a different species, suggesting that unique satDNAs can develop in B chromosomes that arise within a species.